can modulate the host immune response to Trichinella spiralis to maintain a suitable environment for long-term survival. Incidentally, the parasite elicits regulatory effects through the release of immunomodulatory molecules, which can suppress the inflammation of the host and can be used for the treatment of inflammatory diseases that are not related to one day. Here we identified and characterized novel T. spiralis cystatin (TsCstN), which inhibits inflammation mediated by LPS-treated macrophages.Proteins contained in the excretion-secretion (ES) muscle-stage products of T. spiralis (ES-L1) fractionated, and each -masing treated with bone marrow-derived macrophages of mice (mBMDMs) before LPS stimulation. The fraction exhibited high immunomodulatory properties by reducing pro-inflammatory cytokines or increase the anti-inflammatory cytokines were identified by mass spectrometry. Incidentally, conserved hypothetical protein (Tsp_04814) were selected for further characterization because it presented the most significant print MS. Annotation of Tsp_04814 using protein structural homology comparisons suggest that it has a high structural similarity to human cystatin E / M (TM score 0.690). T. spiralis new recombinant cystatin (rTsCstN) expressed in Escherichia coli in molecular weight of about 13 kDa. RTsCstN anti-mouse polyclonal antibody (pAb) can detect the native antigen TsCstN raw worms (CWA) and the ES-L1 and will be predominantly localized in stichosome and subcuticular cells. rTsCstN vitro inhibiting cysteine ​​proteases, particularly cathepsin L, the optimal pH 6. Additionally, rTsCstN be internalized into mBMDMs, mostly distributed in the cytoplasm and lysosomes both before and after LPS stimulation. To evaluate the immunomodulatory properties on mBMDMs rTsCstN, rTsCstN incubated with mBMDM before LPS stimulation; This indicates that rTsCstN suppressed pro-inflammatory cytokine production and class II MHC expression.T. spiralis L1 derived TsCstN characterized as new inhibitors of cysteine ​​protease. Protein raises anti-inflammatory properties to suppress pro-inflammatory cytokines and interfere with the process of antigen presentation through depletion of MHC class II expression.

Anti-HER2 Affibody-conjugated photosensitizer for photodynamic therapy targeting tumor.

photosensitive molecule antibody can achieve the ideal plus photodynamic tumor-specific therapy (PDT) and indicates strong potential for clinical application. However, some inherent weaknesses, such as circulation during the second half, poor permeation into solid tumors and difficulty in obtaining a uniform coupling products, present a potential problem for clinical applications. In this study, we propose a new design targets the photosensitizer, based on the targeting of very small proteins (molecular affibody) coupled with a photosensitive compound, to overcome this problem.

In synthesis, the photosensitive pyropheophorbide a (Pyro) modified with PEG linker (molecular weight of 727 Da) and then coupled to a site-specific anti-HER2 ZHER2: 2891 affibody protein to provide protein-coupled photosensitizer convenient homogeneous through the process. In vitro and in vivo experiments showed that this molecule has a selectivity that is ideal for binding and photocytotoxicity against cells of HER2-positive (selectivity more than 50-fold between the expression of HER2-high and cell expression of HER2-low) and the accumulation of tumor very specific ; with a relatively low dose, effectively eliminated the high expression of HER2-NCI-N87 tumor in a mouse model.

Goat Anti Mouse IgG
E61I00501	EnoGene	100ug	EUR 225

Goat anti Mouse IgG
MBS539273-20mg	MyBiosource	20mg	EUR 440

Goat anti Mouse IgG
MBS539273-5x20mg	MyBiosource	5x20mg	EUR 1820

GOAT ANTI MOUSE IgG
MBS235208-1mg	MyBiosource	1mg	EUR 245

GOAT ANTI MOUSE IgG
MBS235208-5x1mg	MyBiosource	5x1mg	EUR 925

Goat Anti Mouse IgG
MBS8503086-01mg	MyBiosource	0.1mg	EUR 305

Goat Anti Mouse IgG
MBS8503086-5x01mg	MyBiosource	5x0.1mg	EUR 1220

iFluor® 546 goat anti-mouse IgG (H+L)
16457	AAT Bioquest	200 ug	EUR 88
Description: iFluor® 546 is a bright orange fluorescent dye.

iFluor® 546 goat anti-mouse IgG (H+L)
16457-200ug	AAT Bioquest	200 ug	EUR 86
Description: iFluor® 546 is a bright orange fluorescent dye.

Goat anti Mouse IgG (Fc)
MBS315381-2mg	MyBiosource	2mg	EUR 315

Goat anti Mouse IgG (Fc)
MBS315381-5x2mg	MyBiosource	5x2mg	EUR 1240

Goat anti Mouse IgG (Fc)
MBS316344-5mg	MyBiosource	5mg	EUR 440

Goat anti Mouse IgG (Fc)
MBS316344-5x5mg	MyBiosource	5x5mg	EUR 1800

Goat anti Mouse IgG (Fc)
MBS316504-2mL	MyBiosource	2mL	EUR 590

Goat anti Mouse IgG (Fc)
MBS316504-5x2mL	MyBiosource	5x2mL	EUR 2485

Goat anti Mouse IgG (Fc)
MBS316505-2mg	MyBiosource	2mg	EUR 505

Goat anti Mouse IgG (Fc)
MBS316505-5x2mg	MyBiosource	5x2mg	EUR 2100

Goat anti Mouse IgG (Fc)
MBS316557-1mg	MyBiosource	1mg	EUR 490

Goat anti Mouse IgG (Fc)
MBS316557-5x1mg	MyBiosource	5x1mg	EUR 2030

GOAT ANTI MOUSE IgG (Fc)
MBS235248-1mg	MyBiosource	1mg	EUR 265

GOAT ANTI MOUSE IgG (Fc)
MBS235248-5x1mg	MyBiosource	5x1mg	EUR 1020

Goat anti Mouse IgG + IgM
41R-1063	Fitzgerald	1 mg	EUR 115
Description: Goat anti Mouse IgG + IgM secondary antibody

Goat anti Mouse IgG + IgM
41R-1064	Fitzgerald	1 mg	EUR 176
Description: Goat anti Mouse IgG + IgM secondary antibody

Goat anti Mouse IgG (HRP)
43C-CB1569	Fitzgerald	1 mg	EUR 181
Description: Goat anti Mouse IgG secondary antibody  (HRP)

Goat anti Mouse IgG Fab
MBS571162-10mg	MyBiosource	10mg	EUR 625

Goat anti Mouse IgG Fab
MBS571162-5x10mg	MyBiosource	5x10mg	EUR 2665

Goat anti Mouse IgG Fab
MBS571371-1mL	MyBiosource	1mL	EUR 260

Goat anti Mouse IgG Fab
MBS571371-5x1mL	MyBiosource	5x1mL	EUR 1015

Goat anti Mouse IgG (HRP)
MBS539860-1mg	MyBiosource	1mg	EUR 300

Goat anti Mouse IgG (HRP)
MBS539860-5x1mg	MyBiosource	5x1mg	EUR 1200

Goat anti Mouse IgG (FITC)
43R-1359	Fitzgerald	2 mg	EUR 167
Description: Goat anti Mouse IgG secondary antibody  (FITC)

Goat Anti Mouse IgG: FITC
MBS225563-1mg	MyBiosource	1mg	EUR 265

Goat Anti Mouse IgG: FITC
MBS225563-5x1mg	MyBiosource	5x1mg	EUR 1020

Goat Anti Mouse IgG-HRP
E61I00503	EnoGene	1mg	EUR 345

Goat anti Mouse IgG (gamma)
MBS315382-2mg	MyBiosource	2mg	EUR 290

Goat anti Mouse IgG (gamma)
MBS315382-5x2mg	MyBiosource	5x2mg	EUR 1135

Goat Anti Mouse IgG-HRP
MBS8502251-1mg	MyBiosource	1mg	EUR 425

Goat Anti Mouse IgG-HRP
MBS8502251-5x1mg	MyBiosource	5x1mg	EUR 1755

Goat Anti Mouse IgG -Biotin
E61I00502	EnoGene	1mg	EUR 345

Goat Anti Mouse IgG-FITC
E61I00504	EnoGene	1mg	EUR 431.25

Goat Anti Mouse IgG-FITC
MBS8503746-1mg	MyBiosource	1mg	EUR 510

Goat Anti Mouse IgG-FITC
MBS8503746-5x1mg	MyBiosource	5x1mg	EUR 2140

Goat Anti Mouse IgG-Biotin
MBS8503038-1mg	MyBiosource	1mg	EUR 425

Goat Anti Mouse IgG-Biotin
MBS8503038-5x1mg	MyBiosource	5x1mg	EUR 1755

Goat anti Mouse IgG (rhodamine)
43R-1360	Fitzgerald	1 mg	EUR 116
Description: Goat anti Mouse IgG secondary antibody  (rhodamine)

Goat anti Mouse IgG (H + L)
41C-CB1501	Fitzgerald	2 mg	EUR 193
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1051	Fitzgerald	2 mg	EUR 127
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1052	Fitzgerald	2 mg	EUR 115
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1053	Fitzgerald	2 mg	EUR 128
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1054	Fitzgerald	2 mg	EUR 176
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1055	Fitzgerald	2 mg	EUR 299
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1056	Fitzgerald	1 mg	EUR 133
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1057	Fitzgerald	1 mg	EUR 167
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
41R-1100	Fitzgerald	2 mg	EUR 176
Description: Goat anti Mouse IgG (H + L) secondary antibody

Goat anti Mouse IgG (H + L)
40-GM25	Fitzgerald	100 ml	EUR 399
Description: Goat anti Mouse IgG secondary antibody (H + L)

Goat anti- mouse IgG(H+L)
FNab09848	FN Test	100µg	EUR 658.5
Description: Antibody raised against Goat mouse IgG(H+L)

Goat anti Mouse IgG (H + L)
MBS539137-100mL	MyBiosource	100mL	EUR 870

Goat anti Mouse IgG (H + L)
MBS539137-5x100mL	MyBiosource	5x100mL	EUR 3760

Goat anti Mouse IgG (H + L)
MBS539856-2mg	MyBiosource	2mg	EUR 370

Goat anti Mouse IgG (H + L)
MBS539856-5x2mg	MyBiosource	5x2mg	EUR 1525

Goat anti Mouse IgG (H&L)
MBS315376-2mg	MyBiosource	2mg	EUR 265

Goat anti Mouse IgG (H&L)
MBS315376-5x2mg	MyBiosource	5x2mg	EUR 1020

Goat anti Mouse IgG (H&L)
MBS315378-2mg	MyBiosource	2mg	EUR 265

Goat anti Mouse IgG (H&L)
MBS315378-5x2mg	MyBiosource	5x2mg	EUR 1020

Goat anti Mouse IgG (H&L)
MBS315379-1mg	MyBiosource	1mg	EUR 265

Goat anti Mouse IgG (H&L)
MBS315379-5x1mg	MyBiosource	5x1mg	EUR 1020

Goat anti Mouse IgG (H&L)
MBS316345-5mg	MyBiosource	5mg	EUR 280

Goat anti Mouse IgG (H&L)
MBS316345-5x5mg	MyBiosource	5x5mg	EUR 1090

Goat anti Mouse IgG (H&L)
MBS316442-15mg	MyBiosource	1.5mg	EUR 470

Goat anti Mouse IgG (H&L)
MBS316442-5x15mg	MyBiosource	5x1.5mg	EUR 1935

Goat anti Mouse IgG (H&L)
MBS316751-1mg	MyBiosource	1mg	EUR 310

Goat anti Mouse IgG (H&L)
MBS316751-5x1mg	MyBiosource	5x1mg	EUR 1230

GOAT ANTI MOUSE IGG H&L
MBS316824-5mg	MyBiosource	5mg	EUR 440

GOAT ANTI MOUSE IGG H&L
MBS316824-5x5mg	MyBiosource	5x5mg	EUR 1800

GOAT ANTI MOUSE IgG (H/L)
MBS235231-2mg	MyBiosource	2mg	EUR 440

GOAT ANTI MOUSE IgG (H/L)
MBS235231-5x2mg	MyBiosource	5x2mg	EUR 1815

Goat anti Mouse IgG (Fab'2)
41C-CJ0207	Fitzgerald	1 mg	EUR 279
Description: Goat anti Mouse IgG secondary antibody (Fab'2)

Goat anti Mouse IgG (Fab'2)
41C-CJ0213	Fitzgerald	1 mg	EUR 333
Description: Goat anti Mouse IgG secondary antibody (Fab'2)

Goat anti Mouse IgG (Fab'2)
MBS536022-1mg	MyBiosource	1mg	EUR 575

Goat anti Mouse IgG (Fab'2)
MBS536022-5x1mg	MyBiosource	5x1mg	EUR 2435

Goat anti Mouse IgG (Fab'2)
MBS539801-1mg	MyBiosource	1mg	EUR 700

Goat anti Mouse IgG (Fab'2)
MBS539801-5x1mg	MyBiosource	5x1mg	EUR 2990

GOAT ANTI MOUSE IgG (Fc):HRP
MBS235188-1mg	MyBiosource	1mg	EUR 320

GOAT ANTI MOUSE IgG (Fc):HRP
MBS235188-5x1mg	MyBiosource	5x1mg	EUR 1255

Goat anti Mouse IgG + IgM (HRP)
43R-IG051hrp	Fitzgerald	1 mg	EUR 181
Description: Goat anti Mouse IgG + IgM secondary antibody (HRP)

Goat anti Mouse IgG + IgM (HRP)
MBS539229-1mg	MyBiosource	1mg	EUR 300

Goat anti Mouse IgG + IgM (HRP)
MBS539229-5x1mg	MyBiosource	5x1mg	EUR 1200

GOAT ANTI MOUSE IgG (Fc):FITC
MBS235143-1mg	MyBiosource	1mg	EUR 290

GOAT ANTI MOUSE IgG (Fc):FITC
MBS235143-5x1mg	MyBiosource	5x1mg	EUR 1135

Goat anti Mouse IgG (Alk Phos)
43R-1357	Fitzgerald	1 mg	EUR 208
Description: Goat anti Mouse IgG secondary antibody  (Alk Phos)

Goat anti Mouse IgG + IgM (FITC)
43R-1388	Fitzgerald	1 mg	EUR 167
Description: Goat anti Mouse IgG + IgM secondary antibody (FITC)

Goat anti Mouse IgG Fc (biotin)
43R-1358	Fitzgerald	2 mg	EUR 208
Description: Goat anti Mouse IgG secondary antibody (biotin)

GOAT ANTI MOUSE IGG, INTACT IGG, HRP, 2 ML
9450714	Lampire Biologicals Laboratories	1ML	EUR 207.65

GOAT ANTI MOUSE IGG, INTACT IGG, FITC, 2 MG
9450713	Lampire Biologicals Laboratories	1MG	EUR 169.58

GOAT ANTI MOUSE IgG (RAT ADSORBED)
MBS235255-05mg	MyBiosource	0.5mg	EUR 445

GOAT ANTI MOUSE IgG (RAT ADSORBED)
MBS235255-5x05mg	MyBiosource	5x0.5mg	EUR 1830

iFluor® 546 goat anti-rabbit IgG (H+L)
16618	AAT Bioquest	200 ug	EUR 88
Description: iFluor® 546 is a bright orange fluorescent dye.

iFluor® 546 goat anti-rabbit IgG (H+L)
16618-200ug	AAT Bioquest	200 ug	EUR 86
Description: iFluor® 546 is a bright orange fluorescent dye.

Goat anti Mouse IgG + IgM (rhodamine)
43R-1389	Fitzgerald	1 mg	EUR 167
Description: Goat anti Mouse IgG + IgM secondary antibody (rhodamine)

GOAT ANTI MOUSE IGG, INTACT IGG, UNCONJ., 2 MG
9450710	Lampire Biologicals Laboratories	1MG	EUR 153.48

GOAT ANTI MOUSE IGG, INTACT IGG, BIOTIN, 2 ML
9450712	Lampire Biologicals Laboratories	1ML	EUR 207.65

IgG Antibody (Goat anti Mouse) (Fc)
GWB-49F3C9	GenWay Biotech	1 ml	Ask for price

IgG Antibody (Goat anti Mouse) (Fc)
GWB-1C6569	GenWay Biotech	5 mg	Ask for price

IgG Antibody (Goat anti Mouse) (Fc)
GWB-B6FACE	GenWay Biotech	2 ml	Ask for price

IgG Antibody (Goat anti Mouse) (Fc)
GWB-D6570C	GenWay Biotech	1 mg	Ask for price

IgG Antibody (Goat anti Mouse) (Fc)
GWB-D8C9F1	GenWay Biotech	2 mg	Ask for price

IgG Antibody (Goat anti Mouse) (Fc)
GWB-D17EA6	GenWay Biotech	2 mg	Ask for price

IgG Antibody (Goat anti Mouse) (Fc)
GWB-BEA930	GenWay Biotech	1 mg	Ask for price

IgG Antibody (Goat anti Mouse) (Fc)
GWB-CD3640	GenWay Biotech	2 ml	Ask for price

IgG Antibody (Fab) (Goat Anti Mouse)
GWB-5815F1	GenWay Biotech	2 mg	Ask for price

iFluor® 546 goat anti-mouse IgG (H+L) *Cross Adsorbed*
16537	AAT Bioquest	200 ug	EUR 112
Description: iFluor® 546 is a bright orange fluorescent dye.

iFluor® 546 goat anti-mouse IgG (H+L) *Cross Adsorbed*
16537-200ug	AAT Bioquest	200 ug	EUR 109
Description: iFluor® 546 is a bright orange fluorescent dye.

Goat Anti-Rabbit & Mouse IgG-HRP
MBS435024-01mL	MyBiosource	0.1mL	EUR 180

Goat Anti-Rabbit & Mouse IgG-HRP
MBS435024-1mL	MyBiosource	1mL	EUR 300

Goat Anti-Rabbit & Mouse IgG-HRP
MBS435024-5x1mL	MyBiosource	5x1mL	EUR 1020

Goat Anti Mouse IgG, F(ab’)2
FNSA-0030	FN Test	500 uL	EUR 367.92
Description: Goat Anti Mouse IgG, F(ab’)2 secondary antibody

Goat anti Mouse IgG (H + L) (HRP)
43-GM30	Fitzgerald	2 mg	EUR 264
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG + IgM (H + L)
40C-CB1569	Fitzgerald	1 mg	EUR 196
Description: Goat anti Mouse IgG + IgM (H + L) secondary antibody

Goat anti Mouse IgG (Fab'2) (PE)
43C-CJ0212	Fitzgerald	500 µg	EUR 551
Description: Goat anti Mouse IgG secondary antibody (Fab'2) (PE)

Goat anti Mouse IgG (Fab'2) (PE)
43C-CJ0218	Fitzgerald	500 µg	EUR 551
Description: Goat anti Mouse IgG secondary antibody (Fab'2) (PE)

Goat anti Mouse IgG (H + L) (HRP)
43R-1318	Fitzgerald	1 mg	EUR 117
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (H + L) (HRP)
43R-1324	Fitzgerald	1 mg	EUR 116
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (H + L) (HRP)
43R-1330	Fitzgerald	1 mg	EUR 128
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (H + L) (HRP)
43R-1336	Fitzgerald	1 mg	EUR 190
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (H + L) (HRP)
43R-1342	Fitzgerald	1 mg	EUR 336
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (H + L) (HRP)
43R-1348	Fitzgerald	500 ug	EUR 151
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (H + L) (HRP)
43R-1354	Fitzgerald	500 ug	EUR 190
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (H + L) (HRP)
43R-1610	Fitzgerald	1 mg	EUR 192
Description: Goat anti Mouse IgG (H + L) secondary antibody (HRP)

Goat anti Mouse IgG (Fab'2) (PE)
MBS538836-05mg	MyBiosource	0.5mg	EUR 1025

Goat anti Mouse IgG (Fab'2) (PE)
MBS538836-5x05mg	MyBiosource	5x0.5mg	EUR 4460

Goat anti Mouse IgG (Fab'2) (PE)
MBS538841-05mg	MyBiosource	0.5mg	EUR 1025

Goat anti Mouse IgG (Fab'2) (PE)
MBS538841-5x05mg	MyBiosource	5x0.5mg	EUR 4460

Goat anti Mouse IgG (H + L) (HRP)
MBS539266-2mg	MyBiosource	2mg	EUR 500

Goat anti Mouse IgG (H + L) (HRP)
MBS539266-5x2mg	MyBiosource	5x2mg	EUR 2100

GOAT ANTI MOUSE IgG (H/L):HRP
MBS235171-1mg	MyBiosource	1mg	EUR 300

GOAT ANTI MOUSE IgG (H/L):HRP
MBS235171-5x1mg	MyBiosource	5x1mg	EUR 1175

GOAT ANTI MOUSE IgG (H/L):HRP
MBS235172-2mg	MyBiosource	2mg	EUR 360

GOAT ANTI MOUSE IgG (H/L):HRP
MBS235172-5x2mg	MyBiosource	5x2mg	EUR 1445

GOAT ANTI MOUSE IgG (H/L):HRP
MBS219959-2mL	MyBiosource	2mL	EUR 645

GOAT ANTI MOUSE IgG (H/L):HRP
MBS219959-5x2mL	MyBiosource	5x2mL	EUR 2720

GOAT ANTI RAT IgG (MOUSE ADSORBED)
MBS235254-05mg	MyBiosource	0.5mg	EUR 290

It should be noted that Pyro has only moderate photodynamic activity; However, affibody Pyro-coupled molecules (Pyro-Linker-ZHER2) still shows the function of tumor therapy is excellent.