Humulus japonicus (HJ) is a widely used herbal remedy in Asia with anti-oxidative, anti-microbial and anti-inflammatory effects. We investigated the effect of HJ therapeutic potential in rheumatoid arthritis (RA) used a mouse model of collagen-induced arthritis (CIA) and lipopolysaccharide-stimulated murine macrophage cell line (RAW 264.7). CIA rats given 300 mg / kg orally HJ starting 3 days before the second immunization.

Clinical and histopathologic findings assessed in the rat paw CIA. Levels of autoantibodies and inflammatory markers are determined in plasma and cell culture supernatant, respectively. Expression at mRNA and protein levels were analyzed by quantitative reverse transcription-PCR and western blot analysis, respectively. HJ significantly decrease arthritic score dirty and foot swelling in CIA mice. Furthermore, synovial inflammation, cartilage damage and bone erosion that is markedly reduced by HJ.

It also decreased the expression of inflammatory enzymes in both paws of rats and RAW 264.7 cells. Moreover, the expression of genes associated with all pro-inflammatory macrophages and M1 macrophages significantly decreased, whereas the expression of anti-inflammatory M2 macrophage markers was significantly increased in the claws HJ-treated mice CIA. In addition, HJ reduced plasma levels of anti-type II collagen antibody following the decreased expression of T helper type 1 (Th1) and Th2-associated cell surface markers and cytokines in the claws.

HJ also significantly inhibited the expression of IL-6 both in vitro and in vivo, followed by a reduction in STAT3 phosphorylation and expression in rat paw CIA. Finally, the expression of genes associated with decreased osteoclast on HJ-treated rat paw CIA. These findings indicate that the HJ can play a role in suppressing the development of the CIA with the overall regulatory articular inflammation. These studies should provide new insights into the use of the HJ as a natural product effective therapy for RA.

Repeat-Dose Toxicity Studies AFPL1-Conjugate Vaccine Using Nicotine in male Sprague Dawley rats.

Tobacco smoking is the cause of 20% of deaths in Canada per year. Nicotine vaccine presents a promising alternative to traditional smoking cessation products, but until now, no vaccine has been able to move through all phases of clinical trials.

We have previously demonstrated that nicotine AFPL1-conjugate vaccine does not cause systemic or immunotoxicity in this mouse model and that heterologous vaccination approach is more profitable than these homologous to stimulate mucosal and systemic antibody anti-nicotine.

The purpose of this study was to confirm the safety profile of the vaccine in the repeated-dose toxicity studies. Heterologous vaccination strategy re-used, and Sprague-Dawley rats given a dose five times greater than in our previous studies.

Rabbit anti mouse tPA, affinity purified
MBS135145-5x1mg	MyBiosource	5x1mg	EUR 17160

Rabbit anti mouse uPA, affinity purified
MBS135466-01mg	MyBiosource	0.1mg	EUR 750

Rabbit anti mouse uPA, affinity purified
MBS135466-1mg	MyBiosource	1mg	EUR 5295

Affinity Purified Goat anti-Mouse C3 Antibody
MBS560213-01mg	MyBiosource	0.1mg	EUR 250

Affinity Purified Goat anti-Mouse C3 Antibody
MBS560213-5x01mg	MyBiosource	5x0.1mg	EUR 970

Affinity Purified Goat anti-Mouse IgA Antibody
MBS560185-1mg	MyBiosource	1mg	EUR 210

Affinity Purified Goat anti-Mouse IgA Antibody
MBS560185-5x1mg	MyBiosource	5x1mg	EUR 785

Affinity Purified Goat anti-Mouse IgE Antibody
MBS560247-1mg	MyBiosource	1mg	EUR 355

Affinity Purified Goat anti-Mouse IgE Antibody
MBS560247-5x1mg	MyBiosource	5x1mg	EUR 1435

GOAT ANTI MOUSE IGG, AFFINITY PURIFIED, 100 MG
7455507-100MG	Lampire Biologicals Laboratories	1MG	EUR 910.42

GOAT ANTI MOUSE IgG Fab AFFINITY PURIFIED
MBS222005-1mL	MyBiosource	1mL	EUR 460

GOAT ANTI MOUSE IgG Fab AFFINITY PURIFIED
MBS222005-5x1mL	MyBiosource	5x1mL	EUR 1890

Affinity Purified Goat anti-Mouse IgG1 Antibody
MBS560259-1mg	MyBiosource	1mg	EUR 250

Affinity Purified Goat anti-Mouse IgG1 Antibody
MBS560259-5x1mg	MyBiosource	5x1mg	EUR 965

GOAT ANTI MOUSE IGG2, AFFINITY PURIFIED, 100 MG
7455537-100MG	Lampire Biologicals Laboratories	1MG	EUR 1093.43

SHEEP ANTI MOUSE IGG, AFFINITY PURIFIED, 100 MG
7459507-100MG	Lampire Biologicals Laboratories	1MG	EUR 910.42

Affinity purified sheep anti mouse neuroserpin
MBS135205-01mg	MyBiosource	0.1mg	EUR 490

Affinity purified sheep anti mouse neuroserpin
MBS135205-1mg	MyBiosource	1mg	EUR 3815

Affinity purified sheep anti mouse neuroserpin
MBS135205-5x1mg	MyBiosource	5x1mg	EUR 16930

Rabbit anti mouse fibrinogen, affinity purified
MBS135384-01mg	MyBiosource	0.1mg	EUR 620

Rabbit anti mouse fibrinogen, affinity purified
MBS135384-1mg	MyBiosource	1mg	EUR 4125

Rabbit anti mouse fibrinogen, affinity purified
MBS135384-5x1mg	MyBiosource	5x1mg	EUR 18325

Affinity purified sheep anti mouse neuroserpin
MBS480272-01mg	MyBiosource	0.1mg	EUR 545

Affinity purified sheep anti mouse neuroserpin
MBS480272-5x01mg	MyBiosource	5x0.1mg	EUR 2235

DONKEY ANTI MOUSE IGG, AFFINITY PURIFIED, 100 MG
7453507-100MG	Lampire Biologicals Laboratories	1MG	EUR 910.42

GOAT ANTI MOUSE IGG2A, AFFINITY PURIFIED, 100 MG
7455547-100MG	Lampire Biologicals Laboratories	1MG	EUR 1093.43

GOAT ANTI MOUSE IGG2B, AFFINITY PURIFIED, 100 MG
7455557-100MG	Lampire Biologicals Laboratories	1MG	EUR 1093.43

RABBIT ANTI MOUSE IGG, AFFINITY PURIFIED, 100 MG
7457507-100MG	Lampire Biologicals Laboratories	1MG	EUR 1638.07

Anti-Collagen I affinity purified antibody
STJ16101166	St John's Laboratory	1 mL	EUR 457.2

Anti-Collagen II affinity purified antibody
STJ16101167	St John's Laboratory	1 mL	EUR 457.2

Anti-Collagen IV affinity purified antibody
STJ16101169	St John's Laboratory	1 mL	EUR 457.2

Anti-Collagen V affinity purified antibody
STJ16101170	St John's Laboratory	1 mL	EUR 457.2

Anti-Fe65, Affinity Purified Antibody, Rabbit
MBS555150-01mL	MyBiosource	0.1mL	EUR 435

Anti-Fe65, Affinity Purified Antibody, Rabbit
MBS555150-5x01mL	MyBiosource	5x0.1mL	EUR 1815

Anti-Opa1, Affinity Purified Antibody, Rabbit
MBS555158-01mL	MyBiosource	0.1mL	EUR 440

Anti-Opa1, Affinity Purified Antibody, Rabbit
MBS555158-5x01mL	MyBiosource	5x0.1mL	EUR 1840

Rabbit anti mouse PAI-1, affinity purified
MBS135275-01mg	MyBiosource	0.1mg	EUR 710

Rabbit anti mouse PAI-1, affinity purified
MBS135275-1mg	MyBiosource	1mg	EUR 4900

HA Affinity Purified Antibody
MBS194421-1mg	MyBiosource	1mg	EUR 1110

HA Affinity Purified Antibody
MBS194422-INQUIRE	MyBiosource	INQUIRE	Ask for price

T7 Affinity Purified Antibody
MBS194425-INQUIRE	MyBiosource	INQUIRE	Ask for price

T7 Affinity Purified Antibody
MBS194426-INQUIRE	MyBiosource	INQUIRE	Ask for price

V5 Affinity Purified Antibody
MBS194427-INQUIRE	MyBiosource	INQUIRE	Ask for price

V5 Affinity Purified Antibody
MBS194428-INQUIRE	MyBiosource	INQUIRE	Ask for price

HA Affinity Purified Antibody
MBS194468-01mg	MyBiosource	0.1mg	EUR 480

HA Affinity Purified Antibody
MBS194468-5x01mg	MyBiosource	5x0.1mg	EUR 2140

T7 Affinity Purified Antibody
MBS194471-01mg	MyBiosource	0.1mg	EUR 480

T7 Affinity Purified Antibody
MBS194471-5x01mg	MyBiosource	5x0.1mg	EUR 2140

T7 Affinity Purified Antibody
MBS194472-01mg	MyBiosource	0.1mg	EUR 480

T7 Affinity Purified Antibody
MBS194472-5x01mg	MyBiosource	5x0.1mg	EUR 2140

V5 Affinity Purified Antibody
MBS194473-01mg	MyBiosource	0.1mg	EUR 480

V5 Affinity Purified Antibody
MBS194473-5x01mg	MyBiosource	5x0.1mg	EUR 2140

V5 Affinity Purified Antibody
MBS194474-01mg	MyBiosource	0.1mg	EUR 470

V5 Affinity Purified Antibody
MBS194474-5x01mg	MyBiosource	5x0.1mg	EUR 2110

Rabbit anti mouse plasminogen, affinity purified
MBS135134-01mg	MyBiosource	0.1mg	EUR 630

Rabbit anti mouse plasminogen, affinity purified
MBS135134-1mg	MyBiosource	1mg	EUR 4760

Rabbit anti mouse fibronectin, affinity purified
MBS135148-01mg	MyBiosource	0.1mg	EUR 650

Rabbit anti mouse fibronectin, affinity purified
MBS135148-5x01mg	MyBiosource	5x0.1mg	EUR 2685

Anti-Collagen III affinity purified antibody
STJ16101168	St John's Laboratory	1 mL	EUR 457.2

CHICKEN ANTI MOUSE IGG, AFFINITY PURIFIED, 100 MG
7451507-100MG	Lampire Biologicals Laboratories	1MG	EUR 768.4

Affinity purified sheep anti mouse factor X
MBS135424-01mg	MyBiosource	0.1mg	EUR 530

Affinity purified sheep anti mouse factor X
MBS135424-1mg	MyBiosource	1mg	EUR 3475

Affinity purified sheep anti mouse factor X
MBS135424-5x1mg	MyBiosource	5x1mg	EUR 15405

Affinity Purified Sheep Anti Mouse Factor X
MBS480082-01mg	MyBiosource	0.1mg	EUR 585

Affinity Purified Sheep Anti Mouse Factor X
MBS480082-5x01mg	MyBiosource	5x0.1mg	EUR 2415

Affinity Purified Goat anti-Mouse Albumin Antibody
MBS560199-1mg	MyBiosource	1mg	EUR 200

Affinity Purified Goat anti-Mouse Albumin Antibody
MBS560199-5x1mg	MyBiosource	5x1mg	EUR 745

AU1 Affinity Purified Antibody
MBS194409-1mg	MyBiosource	1mg	EUR 1160

AU1 Affinity Purified Antibody
MBS194410-INQUIRE	MyBiosource	INQUIRE	Ask for price

AU5 Affinity Purified Antibody
MBS194411-1mg	MyBiosource	1mg	EUR 1160

AU5 Affinity Purified Antibody
MBS194412-1mg	MyBiosource	1mg	EUR 1160

ECS Affinity Purified Antibody
MBS194415-INQUIRE	MyBiosource	INQUIRE	Ask for price

ECS Affinity Purified Antibody
MBS194416-1mg	MyBiosource	1mg	EUR 1160

KT3 Affinity Purified Antibody
MBS194423-1mg	MyBiosource	1mg	EUR 1160

KT3 Affinity Purified Antibody
MBS194424-1mg	MyBiosource	1mg	EUR 1160

AU1 Affinity Purified Antibody
MBS194455-01mg	MyBiosource	0.1mg	EUR 480

AU1 Affinity Purified Antibody
MBS194455-5x01mg	MyBiosource	5x0.1mg	EUR 2140

AU1 Affinity Purified Antibody
MBS194456-01mg	MyBiosource	0.1mg	EUR 470

AU1 Affinity Purified Antibody
MBS194456-5x01mg	MyBiosource	5x0.1mg	EUR 2110

AU5 Affinity Purified Antibody
MBS194457-01mg	MyBiosource	0.1mg	EUR 470

AU5 Affinity Purified Antibody
MBS194457-5x01mg	MyBiosource	5x0.1mg	EUR 2110

AU5 Affinity Purified Antibody
MBS194458-01mg	MyBiosource	0.1mg	EUR 480

AU5 Affinity Purified Antibody
MBS194458-5x01mg	MyBiosource	5x0.1mg	EUR 2140

ECS Affinity Purified Antibody
MBS194461-01mg	MyBiosource	0.1mg	EUR 480

ECS Affinity Purified Antibody
MBS194461-5x01mg	MyBiosource	5x0.1mg	EUR 2140

ECS Affinity Purified Antibody
MBS194462-01mg	MyBiosource	0.1mg	EUR 480

ECS Affinity Purified Antibody
MBS194462-5x01mg	MyBiosource	5x0.1mg	EUR 2140

KT3 Affinity Purified Antibody
MBS194469-01mg	MyBiosource	0.1mg	EUR 470

KT3 Affinity Purified Antibody
MBS194469-5x01mg	MyBiosource	5x0.1mg	EUR 2110

KT3 Affinity Purified Antibody
MBS194470-01mg	MyBiosource	0.1mg	EUR 470

KT3 Affinity Purified Antibody
MBS194470-5x01mg	MyBiosource	5x0.1mg	EUR 2110

EGR2, Affinity Purified Antibody
MBS555153-01mL	MyBiosource	0.1mL	EUR 435

EGR2, Affinity Purified Antibody
MBS555153-5x01mL	MyBiosource	5x0.1mL	EUR 1815

GOAT ANTI MOUSE IGG, AFFINITY PURIFIED, 10 MG
7455507-10MG	Lampire Biologicals Laboratories	1MG	EUR 147.62

GOAT ANTI MOUSE IGG, AFFINITY PURIFIED, 1 G
7455507-1G	Lampire Biologicals Laboratories	1G	EUR 4547.24

Rabbit anti mouse factor XII, affinity purified
MBS135924-01mg	MyBiosource	0.1mg	EUR 650

Rabbit anti mouse factor XII, affinity purified
MBS135924-1mg	MyBiosource	1mg	EUR 4265

Rabbit anti mouse factor XII, affinity purified
MBS135924-5x1mg	MyBiosource	5x1mg	EUR 18955

Affinity Purified Anti-C/EBP delta Antibody
GWB-1DB9F9	GenWay Biotech	100 ug	Ask for price

GAD67, Affinity Purified Antibody
MBS555616-01mL	MyBiosource	0.1mL	EUR 210

GAD67, Affinity Purified Antibody
MBS555616-5x01mL	MyBiosource	5x0.1mL	EUR 800

GOAT ANTI MOUSE IGG2, AFFINITY PURIFIED, 10 MG
7455537-10MG	Lampire Biologicals Laboratories	1MG	EUR 166.65

GOAT ANTI MOUSE IGG2, AFFINITY PURIFIED, 1 G
7455537-1G	Lampire Biologicals Laboratories	1G	EUR 4911.8

SHEEP ANTI MOUSE IGG, AFFINITY PURIFIED, 10 MG
7459507-10MG	Lampire Biologicals Laboratories	1MG	EUR 147.62

SHEEP ANTI MOUSE IGG, AFFINITY PURIFIED, 1 G
7459507-1G	Lampire Biologicals Laboratories	1G	EUR 4547.24

Nestin, affinity purified antibody
MBS555741-01mL	MyBiosource	0.1mL	EUR 435

Nestin, affinity purified antibody
MBS555741-5x01mL	MyBiosource	5x0.1mL	EUR 1815

DONKEY ANTI MOUSE IGG, AFFINITY PURIFIED, 10 MG
7453507-10MG	Lampire Biologicals Laboratories	1MG	EUR 147.62

DONKEY ANTI MOUSE IGG, AFFINITY PURIFIED, 1 G
7453507-1G	Lampire Biologicals Laboratories	1G	EUR 4547.24

GOAT ANTI MOUSE IGG2A, AFFINITY PURIFIED, 10 MG
7455547-10MG	Lampire Biologicals Laboratories	1MG	EUR 166.65

GOAT ANTI MOUSE IGG2A, AFFINITY PURIFIED, 1 G
7455547-1G	Lampire Biologicals Laboratories	1G	EUR 4911.8

GOAT ANTI MOUSE IGG2B, AFFINITY PURIFIED, 10 MG
7455557-10MG	Lampire Biologicals Laboratories	1MG	EUR 166.65

GOAT ANTI MOUSE IGG2B, AFFINITY PURIFIED, 1 G
7455557-1G	Lampire Biologicals Laboratories	1G	EUR 4911.8

RABBIT ANTI MOUSE IGG, AFFINITY PURIFIED, 10 MG
7457507-10MG	Lampire Biologicals Laboratories	1MG	EUR 220.83

RABBIT ANTI MOUSE IGG, AFFINITY PURIFIED, 1 G
7457507-1G	Lampire Biologicals Laboratories	1G	EUR 6365.65

Affinity Purified Rabbit anti-HA Antibody
MBS560528-1mg	MyBiosource	1mg	EUR 905

Affinity Purified Rabbit anti-HA Antibody
MBS560528-5x1mg	MyBiosource	5x1mg	EUR 3920

Affinity Purified Rabbit anti-HA Antibody
MBS560529-01mg	MyBiosource	0.1mg	EUR 290

Affinity Purified Rabbit anti-HA Antibody
MBS560529-5x01mg	MyBiosource	5x0.1mg	EUR 1155

Affinity Purified Rabbit anti-T7 Antibody
MBS560598-01mg	MyBiosource	0.1mg	EUR 290

Affinity Purified Rabbit anti-T7 Antibody
MBS560598-5x01mg	MyBiosource	5x0.1mg	EUR 1155

Affinity Purified Rabbit anti-V5 Antibody
MBS560608-1mg	MyBiosource	1mg	EUR 905

Affinity Purified Rabbit anti-V5 Antibody
MBS560608-5x1mg	MyBiosource	5x1mg	EUR 3920

Affinity Purified Rabbit anti-V5 Antibody
MBS560609-01mg	MyBiosource	0.1mg	EUR 290

Affinity Purified Rabbit anti-V5 Antibody
MBS560609-5x01mg	MyBiosource	5x0.1mg	EUR 1155

anti-FIPV Antibody (Goat) - Affinity Purified
MBS561155-1mg	MyBiosource	1mg	EUR 455

Goat Anti Mouse IgA Polyclonal Affinity Purified
IGTAMSIGAAP1MG	Innovative research	each	EUR 220
Description: Goat Anti Mouse IgA Polyclonal Affinity Purified

Goat Anti Mouse IgE Polyclonal Affinity Purified
IGTAMSIGEAP1MG	Innovative research	each	EUR 537
Description: Goat Anti Mouse IgE Polyclonal Affinity Purified

Goat Anti Mouse IgG Polyclonal Affinity Purified
IGTAMSIGGAP1MG	Innovative research	each	EUR 132
Description: Goat Anti Mouse IgG Polyclonal Affinity Purified

Goat Anti Mouse IgM Polyclonal Affinity Purified
IGTAMSIGMAP1MG	Innovative research	each	EUR 198
Description: Goat Anti Mouse IgM Polyclonal Affinity Purified

Goat Anti Mouse IgA Polyclonal Affinity Purified
MBS136533-1mg	MyBiosource	1mg	EUR 335

Goat Anti Mouse IgA Polyclonal Affinity Purified
MBS136533-5x1mg	MyBiosource	5x1mg	EUR 1320

Goat Anti Mouse IgE Polyclonal Affinity Purified
MBS136534-1mg	MyBiosource	1mg	EUR 710

Goat Anti Mouse IgE Polyclonal Affinity Purified
MBS136534-5x1mg	MyBiosource	5x1mg	EUR 3000

Goat Anti Mouse IgG Polyclonal Affinity Purified
MBS136541-1mg	MyBiosource	1mg	EUR 250

Goat Anti Mouse IgG Polyclonal Affinity Purified
MBS136541-5x1mg	MyBiosource	5x1mg	EUR 940

Goat Anti Mouse IgM Polyclonal Affinity Purified
MBS136545-1mg	MyBiosource	1mg	EUR 315

Goat Anti Mouse IgM Polyclonal Affinity Purified
MBS136545-5x1mg	MyBiosource	5x1mg	EUR 1240

Cas9 from Steptococcus pyogenes, affinity purified antibody, mouse
MBS555686-01mL	MyBiosource	0.1mL	EUR 435

Cas9 from Steptococcus pyogenes, affinity purified antibody, mouse
MBS555686-5x01mL	MyBiosource	5x0.1mL	EUR 1815

Cas9 from Staphylococcus aureus, affinity purified antibody, mouse
MBS555687-01mL	MyBiosource	0.1mL	EUR 435

Cas9 from Staphylococcus aureus, affinity purified antibody, mouse
MBS555687-5x01mL	MyBiosource	5x0.1mL	EUR 1815

Affinity Purified Rabbit anti-AU1 Antibody
MBS560441-01mg	MyBiosource	0.1mg	EUR 290

Affinity Purified Rabbit anti-AU1 Antibody
MBS560441-5x01mg	MyBiosource	5x0.1mg	EUR 1155

anti-GFP Antibody (Rabbit)-Affinity Purified
MBS561154-01mg	MyBiosource	0.1mg	EUR 300

anti-GFP Antibody (Rabbit)-Affinity Purified
MBS561154-5x01mg	MyBiosource	5x0.1mg	EUR 1200

CHICKEN ANTI MOUSE IGG, AFFINITY PURIFIED, 10 MG
7451507-10MG	Lampire Biologicals Laboratories	1MG	EUR 135.91

CHICKEN ANTI MOUSE IGG, AFFINITY PURIFIED, 1 G
7451507-1G	Lampire Biologicals Laboratories	1G	EUR 4184.14

Goat Anti Mouse IgG1 Polyclonal Affinity Purified
IGTAMSIGG1AP1MG	Innovative research	each	EUR 308
Description: Goat Anti Mouse IgG1 Polyclonal Affinity Purified

Goat Anti Mouse IgG3 Polyclonal Affinity Purified
IGTAMSIGG3AP1MG	Innovative research	each	EUR 308
Description: Goat Anti Mouse IgG3 Polyclonal Affinity Purified

Goat Anti Mouse IgG1 Polyclonal Affinity Purified
MBS136536-1mg	MyBiosource	1mg	EUR 445

Goat Anti Mouse IgG1 Polyclonal Affinity Purified
MBS136536-5x1mg	MyBiosource	5x1mg	EUR 1810

Goat Anti Mouse IgG3 Polyclonal Affinity Purified
MBS136540-1mg	MyBiosource	1mg	EUR 445

Goat Anti Mouse IgG3 Polyclonal Affinity Purified
MBS136540-5x1mg	MyBiosource	5x1mg	EUR 1810

Anti-Bcl-10, Affinity Purified Antibody, Rabbit
MBS555149-01mL	MyBiosource	0.1mL	EUR 425

Anti-Bcl-10, Affinity Purified Antibody, Rabbit
MBS555149-5x01mL	MyBiosource	5x0.1mL	EUR 1760

anti-GFP Antibody (Chicken)-Affinity Purified
MBS561126-05mg	MyBiosource	0.5mg	EUR 805

anti-GFP Antibody (Chicken)-Affinity Purified
MBS561126-5x05mg	MyBiosource	5x0.5mg	EUR 3470

anti-GFP Antibody (Chicken)-Affinity Purified
MBS561127-01mg	MyBiosource	0.1mg	EUR 265

anti-GFP Antibody (Chicken)-Affinity Purified
MBS561127-5x01mg	MyBiosource	5x0.1mg	EUR 1035

D6 Antibody Affinity Purified
MBS540586-01mg	MyBiosource	0.1mg	EUR 445

D6 Antibody Affinity Purified
MBS540586-5x01mg	MyBiosource	5x0.1mg	EUR 1855

D6 Antibody Affinity Purified
MBS540450-01mg	MyBiosource	0.1mg	EUR 445

D6 Antibody Affinity Purified
MBS540450-5x01mg	MyBiosource	5x0.1mg	EUR 1855

Rabbit anti mouse antithrombin III, affinity purified
MBS135448-01mg	MyBiosource	0.1mg	EUR 555

Rabbit anti mouse antithrombin III, affinity purified
MBS135448-1mg	MyBiosource	1mg	EUR 3605

Rabbit anti mouse antithrombin III, affinity purified
MBS135448-5x1mg	MyBiosource	5x1mg	EUR 15990

Goat Anti Mouse IgG2a Polyclonal Affinity Purified
IGTAMSIGG2AAP1MG	Innovative research	each	EUR 308
Description: Goat Anti Mouse IgG2a Polyclonal Affinity Purified

Goat Anti Mouse IgG2b Polyclonal Affinity Purified
IGTAMSIGG2BAP1MG	Innovative research	each	EUR 308
Description: Goat Anti Mouse IgG2b Polyclonal Affinity Purified

Goat Anti Mouse IgG2c Polyclonal Affinity Purified
IGTAMSIGG2CAP1MG	Innovative research	each	EUR 308
Description: Goat Anti Mouse IgG2c Polyclonal Affinity Purified

Rabbit Anti Mouse IgA Polyclonal Affinity Purified
IRBAMSIGAAP1MG	Innovative research	each	EUR 177
Description: Rabbit Anti Mouse IgA Polyclonal Affinity Purified

Rabbit Anti Mouse IgG Polyclonal Affinity Purified
IRBAMSIGGAP1MG	Innovative research	each	EUR 155
Description: Rabbit Anti Mouse IgG Polyclonal Affinity Purified

Rabbit Anti Mouse IgM Polyclonal Affinity Purified
IRBAMSIGMAP1MG	Innovative research	each	EUR 154
Description: Rabbit Anti Mouse IgM Polyclonal Affinity Purified

Rabbit Anti Mouse IgG Polyclonal Affinity Purified
MBS8421216-1mg	MyBiosource	1mg	EUR 270

Rabbit Anti Mouse IgG Polyclonal Affinity Purified
MBS8421216-5x1mg	MyBiosource	5x1mg	EUR 1025

Goat Anti Mouse IgG2a Polyclonal Affinity Purified
MBS136537-1mg	MyBiosource	1mg	EUR 445

Goat Anti Mouse IgG2a Polyclonal Affinity Purified
MBS136537-5x1mg	MyBiosource	5x1mg	EUR 1810

physiological conditions, food and water consumption, body temperature, inflammation of the injection site, relative organ weights, histopathology, and blood chemistry and hematology were evaluated during the vaccination period to determine the safety of the vaccine. AFPL1 nicotine-conjugate vaccine does not induce clinically relevant changes or induces symptoms that would be associated with toxicity, making it a promising candidate for future investigations.