Humulus japonicus (HJ) is a widely used herbal remedy in Asia with anti-oxidative, anti-microbial and anti-inflammatory effects. We investigated the effect of HJ therapeutic potential in rheumatoid arthritis (RA) used a mouse model of collagen-induced arthritis (CIA) and lipopolysaccharide-stimulated murine macrophage cell line (RAW 264.7). CIA rats given 300 mg / kg orally HJ starting 3 days before the second immunization.

Clinical and histopathologic findings assessed in the rat paw CIA. Levels of autoantibodies and inflammatory markers are determined in plasma and cell culture supernatant, respectively. Expression at mRNA and protein levels were analyzed by quantitative reverse transcription-PCR and western blot analysis, respectively. HJ significantly decrease arthritic score dirty and foot swelling in CIA mice. Furthermore, synovial inflammation, cartilage damage and bone erosion that is markedly reduced by HJ.

It also decreased the expression of inflammatory enzymes in both paws of rats and RAW 264.7 cells. Moreover, the expression of genes associated with all pro-inflammatory macrophages and M1 macrophages significantly decreased, whereas the expression of anti-inflammatory M2 macrophage markers was significantly increased in the claws HJ-treated mice CIA. In addition, HJ reduced plasma levels of anti-type II collagen antibody following the decreased expression of T helper type 1 (Th1) and Th2-associated cell surface markers and cytokines in the claws.

HJ also significantly inhibited the expression of IL-6 both in vitro and in vivo, followed by a reduction in STAT3 phosphorylation and expression in rat paw CIA. Finally, the expression of genes associated with decreased osteoclast on HJ-treated rat paw CIA. These findings indicate that the HJ can play a role in suppressing the development of the CIA with the overall regulatory articular inflammation. These studies should provide new insights into the use of the HJ as a natural product effective therapy for RA.

Repeat-Dose Toxicity Studies AFPL1-Conjugate Vaccine Using Nicotine in male Sprague Dawley rats.

Tobacco smoking is the cause of 20% of deaths in Canada per year. Nicotine vaccine presents a promising alternative to traditional smoking cessation products, but until now, no vaccine has been able to move through all phases of clinical trials.

We have previously demonstrated that nicotine AFPL1-conjugate vaccine does not cause systemic or immunotoxicity in this mouse model and that heterologous vaccination approach is more profitable than these homologous to stimulate mucosal and systemic antibody anti-nicotine.

The purpose of this study was to confirm the safety profile of the vaccine in the repeated-dose toxicity studies. Heterologous vaccination strategy re-used, and Sprague-Dawley rats given a dose five times greater than in our previous studies.

Anti-HEK293 HCP, affinity purified
HK293R-AF	Cygnus Technologies	1 mg	EUR 2295.6
Description: Anti-HEK293 HCP, affinity purified by Cygnus Technologies is available in Europe via Gentaur.

Anti-HeLa HCP, Affinity Purified
HL59/73-AF	Cygnus Technologies	1 mg	EUR 2295.6
Description: Anti-HeLa HCP, Affinity Purified by Cygnus Technologies is available in Europe via Gentaur.

Sheep Anti-Mouse IgG, Affinity Purified (Bulk)
43319-SAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Rabbit Anti-Mouse IgG, Affinity Purified (Bulk)
44319-RAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Donkey Anti-Mouse IgG, Affinity Purified (Bulk)
42319-DAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Mouse IgG, Affinity Purified (Bulk)
41319-CAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Mouse IgG2b, Affinity Purified (Bulk)
40123-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Mouse IgG1, Affinity Purified (Bulk)
40126-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Mouse IgG2a, Affinity Purified (Bulk)
40127-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Rabbit anti-Mouse Moesin IgG, affinity purified
MSN11-A	Alpha Diagnostics	100 ul	EUR 578.4

anti-Dnmt1 (1-248) antibody, affinity-purified
70-201	Sceti	50ug	EUR 417.6
Description: The anti-Dnmt1 (1-248) antibody, affinity-purified is available in Europe and for worldwide shipping via Gentaur.

anti-HP1? /CBX5 antibody (rabbit) affinity purified
70-221	Sceti	50ug	EUR 355.2
Description: The anti-HP1? /CBX5 antibody (rabbit) affinity purified is available in Europe and for worldwide shipping via Gentaur.

anti-HP1? /CBX1 antibody (rabbit) affinity purified
70-223	Sceti	50ug	EUR 355.2
Description: The anti-HP1? /CBX1 antibody (rabbit) affinity purified is available in Europe and for worldwide shipping via Gentaur.

anti-HP1? /CBX3 antibody (rabbit) affinity purified
70-225	Sceti	50ug	Ask for price
Description: The anti-HP1? /CBX3 antibody (rabbit) affinity purified is available in Europe and for worldwide shipping via Gentaur.

Anti-Per.C6Ð’ Affinity Purified HRP, Goat
PC118AF-HRP	Cygnus Technologies	1 mg	EUR 4882.8
Description: Anti-Per.C6Ð’ Affinity Purified HRP, Goat by Cygnus Technologies is available in Europe via Gentaur.

anti-Vero Cell HCP, Affinity Purified
VC807-AFB	Cygnus Technologies	1 mg	EUR 4143.6
Description: anti-Vero Cell HCP, Affinity Purified by Cygnus Technologies is available in Europe via Gentaur.

Anti-Vero Cell HCP affinity purified
VC807.5-AF	Cygnus Technologies	0.5 mg	EUR 1926
Description: Anti-Vero Cell HCP affinity purified by Cygnus Technologies is available in Europe via Gentaur.

Mouse Monoclonal Anti-Human IgG, Affinity Purified (Bulk)
10129-MAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Modified Affinity Purified Avidin
7-04469	CHI Scientific	10mg	Ask for price

Modified Affinity Purified Avidin
7-04470	CHI Scientific	100mg	Ask for price

Modified Affinity Purified Avidin
7-04468	CHI Scientific	2mg	Ask for price

Rabbit Anti-Human Haptoglobin Polyclonal Antibody(Affinity Purified)
DPAB2047RH	Creative Diagnostics	1mg	EUR 696

Donkey Anti-Goat IgG, Affinity Purified (Bulk)
60319-DAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Rabbit Anti-Goat IgG, Affinity Purified (Bulk)
60319-RAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Rat IgG, Affinity Purified (Bulk)
50319-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Human IgA, Affinity Purified (Bulk)
10019-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Human IgG, Affinity Purified (Bulk)
10119-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Rabbit Anti-Human IgG, Affinity Purified (Bulk)
10119-RAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Donkey Anti-Sheep IgG, Affinity Purified (Bulk)
30326-CAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Monoclonal Anti-Dog IgE, affinity purified, unlabeled
30389	Alpha Diagnostics	100 ug	EUR 416.4

Donkey Anti-Sheep IgG, Affinity Purified (Bulk)
30518-DAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Rabbit IgG, Affinity Purified (Bulk)
20318-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Sheep Anti-Rabbit IgG, Affinity Purified (Bulk)
20319-SAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Donkey Anti-Rabbit IgG, Affinity Purified (Bulk)
20320-DAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Sheep Anti-Digoxigenin IgG, unlabeled, affinity purified
DGX11-A	Alpha Diagnostics	1 mg	EUR 489.6

Goat Anti-Mouse IgG, Fc Fragment, Affinity Purified (Bulk)
40151-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Mouse IgM, µ Chain, Affinity Purified (Bulk)
40221-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 418.8

Modified Affinity Purified Avidin Protein
20-abx263157	Abbexa	EUR 1646.40 EUR 393.60 EUR 276.00	100 mg 10 mg 2 mg

Donkey Anti-Goat IgG (Fc), unlabeled, affinity purified
30230	Alpha Diagnostics	1 mg	EUR 242.4

Monoclonal Anti-Dog IgE-Biotin conjugate, affinity purified
30389-B	Alpha Diagnostics	0.5 ml	EUR 489.6

Monoclonal Anti-Dog IgE-FITC conjugate, affinity purified
30389-F	Alpha Diagnostics	0.5 ml	EUR 489.6

Rabbit Anti-Llama IgG (heavy chain), Affinity Purified
30840-UL	Alpha Diagnostics	200 ug	EUR 242.4

Rabbit Anti-Llama IgG (light chain), Affinity Purified
30845-UL	Alpha Diagnostics	200 ug	EUR 242.4

Goat Anti-Human IgM, Myeloma, Affinity Purified (Bulk)
10217-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Human IgM, Plasma, Affinity Purified (Bulk)
10218-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Rabbit anti-Pichia pastoris (HCPs) IgG, affinity purified
800-150-PPS	Alpha Diagnostics	100 ul	EUR 548.4

Rabbit anti-Human CD40 IgG, affinity purified, unlabeled
CD4011-A	Alpha Diagnostics	100 ug	EUR 578.4

Chicken Anti-Protein A IgG, Affinity Purified (Bulk)
PRTA-CAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Anti-SF9 Insect Cell HCP 2G affinity purified
SF9RB01-AF	Cygnus Technologies	0.5 mg	EUR 2295.6
Description: Anti-SF9 Insect Cell HCP 2G affinity purified by Cygnus Technologies is available in Europe via Gentaur.

Mouse Monoclonal Anti-Human IgM, clone 1, Affinity Purified (Bulk)
10221-MAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Mouse Monoclonal Anti-Human IgM, clone 2, Affinity Purified (Bulk)
10222-MAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Glutathione-S-transferase (GST) Affinity Purified Antibody
20-abx137511	Abbexa	EUR 994.80 EUR 393.60 EUR 260.40	100 ug 20 ug 5 ug

dsDNA-cellulose (affinity support) (for removing autoantibodies to dsDNA or DNA-binding proteins)
DNAD15-AS	Alpha Diagnostics	100 mg	EUR 270

ssDNA-cellulose (affinity support) (for removing autoantibodies to ssDNA or DNA-binding proteins)
DNAS25-AS	Alpha Diagnostics	100 mg	EUR 270

Biotin Modified Affinity Purified Avidin protein
PROTP02701	BosterBio	Regular: 10mg	EUR 380.4
Description: Avidin is a basic charged glycoprotein present in the egg white and in some extent in tissues of various animals. Avidin is a homotetrameric protein that contains 4 identical subunits which bind to Biotin with high extent of affinity and specificity consisting of 128 amino acids and has a molecular mass of about 67K Daltons. ;Avidin-Biotin is a modified form of affinity purified avidin that combines the high affinity specific activity of the native egg white avidin to biotin molecule together with a very low background of the streptavidin produced by the bacteria Streptomyces avidinii.

Goat Anti-Human IgG, Fc Fragment, Affinity Purified (Bulk)
10118-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Rabbit IgG, Fc Fragment, Affinity Purified (Bulk)
20119-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Human IgM, µ Chain, Affinity Purified (Bulk)
10219-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Llama IgG (H+L chain), Affinity Purified (Bulk)
30817-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Rabbit Anti-Llama IgG (H+L chain), Affinity Purified (Bulk)
30818-RAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Goat Anti-Human IgM, Fc (5u specific), Affinity Purified (Bulk)
10216-GAF-BLK	Alpha Diagnostics	1g; bulk	Ask for price

Purified Human C1q protein for ELISA or Standards
C1Q15-N	Alpha Diagnostics	100 ug	EUR 300

Purified Human C1q protein for ELISA or Standards
C1Q15-N-1000	Alpha Diagnostics	1000 ug	EUR 1000.8

Purified, Bovine S100 protein for ELISA or Standards
S1001-R-200	Alpha Diagnostics	200 ug	EUR 388.8

Purified, Human S100 protein for ELISA or Standards
S1002-R-100	Alpha Diagnostics	100 ug	EUR 388.8

Purified bovine histones (H1, H2a, H2b, H3)-Agarose affinity support for removing autoantibdies to histones
HIST15-AS-1	Alpha Diagnostics	0.5 ml	EUR 416.4

Purified Anti-mouse CD19 Antibody *1D3*
10194000	AAT Bioquest	100 ug	EUR 164

Purified Anti-mouse CD197 Antibody *4B12*
11970000	AAT Bioquest	100 ug	EUR 365

OR Antibody
44609-100ul	SAB	100ul	EUR 302.4

OR Antibody
44609-50ul	SAB	50ul	EUR 224.4

OR Antibody
ABD10250	Lifescience Market	100 ug	EUR 525.6

OR Antibody
20-abx217389	Abbexa	EUR 510.00 EUR 410.40	100 ug 50 ug

OR Antibody
DF10250	Affbiotech	200ul	EUR 420

Mouse anti-Human CD4, Purified mAbConjugated Antibody
C28010	SAB	100ul	EUR 476.4

Mouse anti-Human CD8, Purified mAbConjugated Antibody
C28025	SAB	100ul	EUR 476.4

Mouse anti-Human CD14, Purified mAbConjugated Antibody
C28050	SAB	100ul	EUR 476.4

Mouse anti-Human CD19, Purified mAbConjugated Antibody
C28071	SAB	100ul	EUR 476.4

Mouse anti-Human CD45, Purified mAbConjugated Antibody
C28141	SAB	100ul	EUR 476.4

Purified Anti-mouse CD105 Antibody *MJ7/18*
11050000	AAT Bioquest	100 ug	EUR 365

Purified Anti-mouse CD106 Antibody *429 (MVCAM.A)*
11060000	AAT Bioquest	100 ug	EUR 365

Purified Anti-mouse CD26 Antibody *H194-112*
10260000	AAT Bioquest	100 ug	EUR 365

Purified Anti-human/mouse CD44 Antibody *IM7*
10441000	AAT Bioquest	100 ug	EUR 164

Purified Anti-mouse CD86 Antibody *GL-1*
10860000	AAT Bioquest	100 ug	EUR 365

Anti-Flag Affinity Gel
B23101	Bimake	1 ml Kit	EUR 579.6
Description: Anti-Flag Affinity Gel is a Protein A purIFied murine IgG2b Monoclonal antibody covalently attached to sepharose 4B wHICh could used on Flag fusion protein purIFication, IP and CO-IP.

Anti-Flag Affinity Gel
B23102	Bimake	5 ml Kit	EUR 1742.4
Description: Anti-Flag Affinity Gel is a Protein A purIFied murine IgG2b Monoclonal antibody covalently attached to sepharose 4B wHICh could used on Flag fusion protein purIFication, IP and CO-IP.

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 336

Anti-SOS Purified
11-522-C025	ExBio	0.025 mg	EUR 129.6

Anti-SOS Purified
11-522-C100	ExBio	0.1 mg	EUR 212.4

Anti-PKAc Purified
11-523-C025	ExBio	0.025 mg	EUR 129.6

Anti-PKAc Purified
11-523-C100	ExBio	0.1 mg	EUR 212.4

Anti-SHIP1 Purified
11-524-C025	ExBio	0.025 mg	EUR 129.6

Anti-SHIP1 Purified
11-524-C100	ExBio	0.1 mg	EUR 212.4

Anti-SHIP1 Purified
11-525-C025	ExBio	0.025 mg	EUR 129.6

Anti-SHIP1 Purified
11-525-C100	ExBio	0.1 mg	EUR 212.4

Anti-LST1 Purified
11-528-C025	ExBio	0.025 mg	EUR 146.4

Anti-LST1 Purified
11-528-C100	ExBio	0.1 mg	EUR 244.8

Anti-PSMA Purified
11-532-C025	ExBio	0.025 mg	EUR 151.2

Anti-PSMA Purified
11-532-C100	ExBio	0.1 mg	EUR 255.6

Anti-CRP Purified
11-537-C100	ExBio	0.1 mg	EUR 244.8

Anti-PSMA Purified
11-539-C025	ExBio	0.025 mg	EUR 151.2

Anti-PSMA Purified
11-539-C100	ExBio	0.1 mg	EUR 255.6

Anti-AHNAK1 Purified
11-540-C025	ExBio	0.025 mg	EUR 146.4

Anti-AHNAK1 Purified
11-540-C100	ExBio	0.1 mg	EUR 244.8

Anti-BRG1 Purified
11-541-C025	ExBio	0.025 mg	EUR 146.4

Anti-BRG1 Purified
11-541-C100	ExBio	0.1 mg	EUR 244.8

Anti-CPNE7 Purified
11-542-C025	ExBio	0.025 mg	EUR 151.2

Anti-CPNE7 Purified
11-542-C100	ExBio	0.1 mg	EUR 255.6

Anti-GRB2 Purified
11-554-C025	ExBio	0.025 mg	EUR 146.4

Anti-GRB2 Purified
11-554-C100	ExBio	0.1 mg	EUR 244.8

Anti-AGR3 Purified
11-560-C025	ExBio	0.025 mg	EUR 178.8

Anti-AGR3 Purified
11-560-C100	ExBio	0.1 mg	EUR 309.6

Anti-AGR3 Purified
11-561-C025	ExBio	0.025 mg	EUR 178.8

Anti-AGR3 Purified
11-561-C100	ExBio	0.1 mg	EUR 309.6

Anti-UBN1 Purified
11-565-C025	ExBio	0.025 mg	EUR 146.4

Anti-UBN1 Purified
11-565-C100	ExBio	0.1 mg	EUR 244.8

Anti-GFAP Purified
11-583-C025	ExBio	0.025 mg	EUR 135.6

Anti-GFAP Purified
11-583-C100	ExBio	0.1 mg	EUR 223.2

Anti-FoxP3 Purified
11-601-C025	ExBio	0.025 mg	EUR 163.2

Anti-FoxP3 Purified
11-601-C100	ExBio	0.1 mg	EUR 277.2

Anti-PRR7 Purified
11-617-C025	ExBio	0.025 mg	EUR 168

Anti-PRR7 Purified
11-617-C100	ExBio	0.1 mg	EUR 288

Anti-ABRA1 Purified
11-619-C025	ExBio	0.025 mg	EUR 146.4

Anti-ABRA1 Purified
11-619-C100	ExBio	0.1 mg	EUR 244.8

Anti-GRAP2 Purified
11-639-C025	ExBio	0.025 mg	EUR 146.4

Anti-GRAP2 Purified
11-639-C100	ExBio	0.1 mg	EUR 244.8

Anti-Notch1 Purified
11-651-C025	ExBio	0.025 mg	EUR 118.8

Anti-Notch1 Purified
11-651-C100	ExBio	0.1 mg	EUR 189.6

Anti-PDK1 Purified
11-659-C100	ExBio	0.1 mg	EUR 244.8

Anti-ZAP70 Purified
11-665-C025	ExBio	0.025 mg	EUR 129.6

Anti-ZAP70 Purified
11-665-C100	ExBio	0.1 mg	EUR 212.4

Anti-EGFR Purified
11-680-C025	ExBio	0.025 mg	EUR 140.4

Anti-EGFR Purified
11-680-C100	ExBio	0.1 mg	EUR 234

Anti-BrdU Purified
11-682-C025	ExBio	0.025 mg	EUR 129.6

Anti-BrdU Purified
11-682-C100	ExBio	0.1 mg	EUR 212.4

Anti-Nitrotyrosine Purified
11-693-C025	ExBio	0.025 mg	EUR 189.6

Anti-Nitrotyrosine Purified
11-693-C100	ExBio	0.1 mg	EUR 332.4

Anti-Drebrin Purified
11-694-C025	ExBio	0.025 mg	EUR 146.4

Anti-Drebrin Purified
11-694-C100	ExBio	0.1 mg	EUR 244.8

Anti-FOLR2 Purified
11-696-C025	ExBio	0.025 mg	EUR 118.8

Anti-FOLR2 Purified
11-696-C100	ExBio	0.1 mg	EUR 189.6

Anti-PCLO Purified
11-698-C025	ExBio	0.025 mg	EUR 146.4

Anti-PCLO Purified
11-698-C100	ExBio	0.1 mg	EUR 244.8

Anti-OPAL1 Purified
11-699-C025	ExBio	0.025 mg	EUR 146.4

Anti-OPAL1 Purified
11-699-C100	ExBio	0.1 mg	EUR 244.8

Anti-CLIC5 Purified
11-701-C025	ExBio	0.025 mg	EUR 146.4

Anti-CLIC5 Purified
11-701-C100	ExBio	0.1 mg	EUR 244.8

Anti-LARGE1 Purified
11-702-C025	ExBio	0.025 mg	EUR 146.4

Anti-LARGE1 Purified
11-702-C100	ExBio	0.1 mg	EUR 244.8

Anti-SCIMP Purified
11-704-C025	ExBio	0.025 mg	EUR 146.4

Anti-SCIMP Purified
11-704-C100	ExBio	0.1 mg	EUR 244.8

Anti-TFG Purified
11-709-C025	ExBio	0.025 mg	EUR 146.4

Anti-TFG Purified
11-709-C100	ExBio	0.1 mg	EUR 244.8

Anti-PDE8A Purified
11-710-C025	ExBio	0.025 mg	EUR 146.4

Anti-PDE8A Purified
11-710-C100	ExBio	0.1 mg	EUR 244.8

Anti-NCK1 Purified
11-711-C025	ExBio	0.025 mg	EUR 146.4

Anti-NCK1 Purified
11-711-C100	ExBio	0.1 mg	EUR 244.8

Anti-DLL4 Purified
11-717-C025	ExBio	0.025 mg	EUR 103.2

Anti-DLL4 Purified
11-717-C100	ExBio	0.1 mg	EUR 157.2

Anti-RLTPR Purified
11-718-C025	ExBio	0.025 mg	EUR 146.4

Anti-RLTPR Purified
11-718-C100	ExBio	0.1 mg	EUR 244.8

Anti-NR2F6 Purified
11-719-C025	ExBio	0.025 mg	EUR 146.4

Anti-NR2F6 Purified
11-719-C100	ExBio	0.1 mg	EUR 244.8

Anti-ARHGEF4 Purified
11-723-C025	ExBio	0.025 mg	EUR 129.6

Anti-ARHGEF4 Purified
11-723-C100	ExBio	0.1 mg	EUR 212.4

Anti-DDIT4L Purified
11-725-C025	ExBio	0.025 mg	EUR 146.4

Anti-DDIT4L Purified
11-725-C100	ExBio	0.1 mg	EUR 244.8

Anti-AGPS Purified
11-739-C025	ExBio	0.025 mg	EUR 146.4

Anti-AGPS Purified
11-739-C100	ExBio	0.1 mg	EUR 244.8

Anti-LRRC32 Purified
11-744-C025	ExBio	0.025 mg	EUR 118.8

Anti-LRRC32 Purified
11-744-C100	ExBio	0.1 mg	EUR 189.6

Anti-DR3 Purified
11-757-C025	ExBio	0.025 mg	EUR 118.8

Anti-DR3 Purified
11-757-C100	ExBio	0.1 mg	EUR 189.6

Anti-Perforin Purified
11-765-C025	ExBio	0.025 mg	EUR 129.6

Anti-Perforin Purified
11-765-C100	ExBio	0.1 mg	EUR 212.4

physiological conditions, food and water consumption, body temperature, inflammation of the injection site, relative organ weights, histopathology, and blood chemistry and hematology were evaluated during the vaccination period to determine the safety of the vaccine. AFPL1 nicotine-conjugate vaccine does not induce clinically relevant changes or induces symptoms that would be associated with toxicity, making it a promising candidate for future investigations.